Reconstitution procedure. Skin And Subcutaneous Disorders: Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), erythema multiforme and acute generalized exanthematous pustulosis. In the Merrem IV treated group, 12/15 patients with seizures had late onset seizures (defined as occurring on day 3 or later) versus 7/20 in the comparator arm. Anemia If experienced, these tend to have a Less Severe expression 1. Merrem IV (meropenem injection) side effects list for healthcare professionals. A severe and sometimes deadly reaction has happened. Merrem IV (meropenem) is an antibiotic used to treat certain types of bacterial infections. The following adverse reaction frequencies were derived from the clinical trials in the 2904 patients treated with Worldwide post-marketing adverse reactions not otherwise listed in the Adverse Reactions from Clinical Trials section of this prescribing information and reported as possibly, probably, or definitely drug related are listed within each body system in order of decreasing severity. The types of systemic and local adverse events seen in these patients are similar to the adults, with the most common adverse reactions reported as possibly, probably, or definitely related to MERREM IV and their rates of occurrence as follows: In the meningitis studies, the rates of seizure activity during therapy were comparable between patients with no CNS abnormalities who received meropenem and those who received comparator agents (either cefotaxime or ceftriaxone). Most people who take Merrem (meropenem) usually have few side effects. Examples of strains include: EHEC (enterohemorrhagic E. coli), ETEC (enterotoxigenic E. coli), EPEC (enteropathogenic E. coli), EIEC (enteroinvasive E. coli), EAEC (enteroadherent E. coli), and EAggEC (enteroaggregative E. coli). If any of these effects last or get worse, tell your doctor or pharmacist promptly. confusion. Visit the FDA MedWatch website or call 1-800-FDA-1088. The adverse reactions seen in these patients that were reported and their rates of occurrence are as follows: Adverse Laboratory Changes in Pediatric Patients. Diarrhea 4. Merrem is used in the treatment of infections of the abdomen, such as appendicitis and peritonitis, bacterial meningitis (infection of the lining of the brain), and skin infections. Merrem IV (meropenem injection) is a carbapenem antibiotic used to treat a variety of bacteria. The types of systemic and local adverse events seen in these patients are similar to the adults, with the most common adverse reactions reported as possibly, probably, or definitely related to Merrem IV and their rates of occurrence as follows: In the meningitis studies, the rates of seizure activity during therapy were comparable between patients with no CNS abnormalities who received meropenem and those who received comparator agents (either cefotaxime or ceftriaxone). In a study of complicated skin and skin structure infections, the adverse reactions were similar to those listed above. Pneumonia may be contagious for 2-14 days. Upset stomach, headache, nausea, vomiting, constipation, or diarrhea may also occur. Most pneumonias are caused by bacteria and viruses, but some pneumonias are caused by inhaling toxic chemicals that damage lung tissue. Meningitis, inflammation of the meninges, symptoms and signs include neck stiffness, headache, and fever. Call your doctor for medical advice about side effects. It is unknown if Merrem IV enters breast milk. If inflammation affects both lungs, the infection is termed double pneumonia. Complicated Skin and Skin Structure Infections Swelling at the injection site. Use in pregnancy appears to be safe. Adverse laboratory changes that were reported and occurring in greater than 0.2% of the patients were as follows: Hepatic: increased alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase, lactate The following adverse reaction frequencies were derived from the clinical trials in the 2904 patients treated with The following adverse reactions have been identified during post-approval use of Merrem IV. The walls are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together. Satisfactory bacteriologic response was 80% in the meropenem group and 75% in the imipenem/cilastatin group. Systemic adverse events that were reported with MERREM IV occurring in greater than 1.0% of the patients were diarrhea (4.8%), nausea/vomiting (3.6%), headache (2.3%), rash (1.9%), sepsis (1.6%), constipation (1.4%), apnea (1.3%), shock (1.2%), and pruritus (1.2%). Amropenem (500 mg) 500mg - 1 Vial Injection (Meropenem) drug information. Merrem IV (meropenem injection) is a carbapenem antibiotic used to treat a variety of bacteria, including E. coli, H. influenzae, K. pneumoniae, N. meningitidis, P. aeruginosa, and others. Bacterial Infections 101 Pictures Slideshow, E. coli 0157:H7 (Escherichia coli 0157:H7), E. Coli Outbreaks in Potato Salad and Wading Pool. Merrem (meropenem) is available as a generic. Read the entire detailed patient monograph for Merrem IV (Meropenem). By continuing to browse this site you are agreeing to our use of cookies. E coli O157:H7 commonly is due to eating raw or undercooked hamburger or raw milk or dairy products. There are five types of meningitis: viral, bacterial, fungal, parasitic, and noninfectious. Transiently elevated liver enzymes were the most common side-effect. soreness, redness, or swelling at the injection site. Decreased urine output. This is not a complete list of side effects and others may occur. depression, asthenia, Respiratory: respiratory disorder, dyspnea, pleural effusion, asthma, cough increased, lung edema, Skin and Appendages: urticaria, sweating, skin ulcer, Urogenital System: dysuria, kidney failure, vaginal moniliasis, urinary incontinence. Merrem IV prevents bacteria from forming the walls that surround them. home Meninges act as a protective layer to the brain and spinal cord. Treatment of meningitis depends upon the cause of the infection and may include antibiotics or antiviral medications. Merrem (meropenem) may make you feel weak or confused. species. Serious adverse effects are rare. Complications of E. coli infection include hemorrhagic diarrhea, hemolytic-uremic syndrome, and thrombotic thrombocytopenic purpura. Side effects of Merrem include nausea, vomiting, diarrhea, constipation, headache, or soreness, redness, or swelling at the injection site. Check with your doctor or nurse immediately if any of the following side effects occur: Less common. E. coli spreads from person to person via contaminated food or fainting. Please report all side effects to the doctor or nurse. MERREM IV. Upset stomach, headache, nausea, vomiting, constipation, or diarrhea may also occur. Local adverse events that were reported with MERREM IV were as follows: Systemic adverse events that were reported with MERREM IV occurring in greater than 1.0% of the patients were The most common adverse events occurring in greater than 5% of the patients were: headache (7.8%), nausea (7.8%), constipation (7.0%), diarrhea (7.0%), anemia (5.5%), and pain (5.1%). Case reports in the literature have shown that co-administration of carbapenems, including meropenem, to patients receiving valproic acid or divalproex sodium results in a reduction in valproic acid concentrations. Serious side effects include Clostridium difficile infection, seizures, and allergic reactions including anaphylaxis. Many patients in these trials were severely ill and had multiple background diseases, physiological impairments and were receiving multiple other drug therapies. Diarrhea. For patients with varying degrees of renal impairment, the incidence of heart failure, kidney failure, seizure and shock reported with MERREM IV, increased in patients with moderately severe renal impairment (creatinine clearance 10 to 26 mL/min) [see DOSAGE AND ADMINISTRATION,WARNINGS AND PRECAUTIONS, Use In Specific Populations and leukocytosis, hypokalemia, Renal: increased creatinine and increased blood urea nitrogen (BUN). It is administered intravenously. You are encouraged to report negative side effects of prescription drugs to the FDA. water. Symptoms and signs include cough, fever, shortness of breath, and chills. Terms of Use. Antibiotics treat pneumonia, and the choice of the antibiotic depends upon the cause of the infection. A second infection may happen. decreasing the serum concentrations of valproic acid. These may be encountered; Pain at the site of injection. The most common adverse events occurring in greater than 5% of the patients were: Adverse events with an incidence of greater than 1%, and not listed above, include: For patients with varying degrees of renal impairment, the incidence of heart leukocytosis, hypokalemia, Renal: increased creatinine and increased blood urea nitrogen (BUN). dizziness. Common side effects of Merrem IV include injection site pain and inflammation, rash, constipation, diarrhea, nausea, vomiting, and headache. What is meningitis and what causes it? Pneumonia can be deadly. Symptoms may vary depending on the strain the individual contracts. somnolence, anxiety, depression, asthenia [see WARNINGS AND PRECAUTIONS], Respiratory: respiratory disorder, dyspnea, pleural effusion, asthma, cough increased, lung edema, Skin and Appendages: urticaria, sweating, skin ulcer, Urogenital System: dysuria, kidney failure, vaginal moniliasis, urinary incontinence. Meropenem and vaborbactam injection may cause side effects. Safe and effective use of Merrem IV is not established in pregnant females. Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for MEROPENEM. Pediatric Patients with Serious Bacterial Infections (excluding Bacterial Meningitis): Merrem IV was studied in 515 pediatric patients (3 months to less than 13 years of age) with serious bacterial infections (excluding meningitis, see next section) at dosages of 10 mg/kg to 20 mg/kg every 8 hours. Vomiting bradycardia, hypotension, syncope, Digestive System: oral moniliasis, anorexia, cholestatic jaundice/jaundice, flatulence, ileus, hepatic failure, dyspepsia, Get our free fact sheet. In case of a severe side effect or reaction, call the doctor, nurse or pharmacist at 595-3300. Abdominal pain. Meropenem may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. If … The following adverse reactions have been identified during post-approval use of MERREM IV. hematocrit, decreased white blood cell (WBC), shortened prothrombin time and shortened partial thromboplastin time, {{configCtrl2.info.metaDescription}} This site uses cookies. Safe and effective use of Merrem IV is not established in pregnant females. Side effects of Merrem include: nausea, vomiting, diarrhea, constipation, headache, or soreness, redness, or swelling at the injection site. Take the Pneumonia Quiz on MedicineNet to learn more about this highly contagious, infectious disease. Below is a summary of known side effects for MERREM IV. When taking Merrem (meropenem), you might experience stiff muscles or abnormal muscle movements. The following are discussed in greater detail in other sections of labeling: Because clinical trials are conducted under widely varying conditions, adverse reactions rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Swelling and redness at the injection site. A Skin Rash 2. Symptoms and signs of E. coli infection include diarrhea, stomach cramps, and sometimes fever. (1.3%), shock (1.2%), and pruritus (1.2%). Confusion. Pneumonia is inflammation of the lungs caused by fungi, bacteria, or viruses. Digestive Disorders: Common Misconceptions. Co-administration of meropenem IV with valproic acid or divalproex sodium reduces serum concentrations of valproic acid potentially increasing risk of breakthrough seizures. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). Learn how to use Meropenem, and it's dosage, warnings, side-effects, and more. One patient treated with imipenem/cilastatin experienced a seizure during the study, while another patient treated with meropenem withdrew due to urticaria. The types of systemic and local adverse events seen in these patients are similar to the adults, with the most common adverse events reported as possibly, probably, or definitely related to MERREM IV and their rates of occurrence as follows: Pediatric Patients with Bacterial Meningitis. In the seriously ill patient population, it was not possible to determine the relationship between observed adverse events and therapy with MERREM IV. Pneumonia Vaccination: Who Should Have One? Serious side effects of Merrem IV include. and animal studies suggest that carbapenems may inhibit the hydrolysis of Although not all of these side effects may occur, if they do occur they may need medical attention. Tell your doctor or nurse right away if you or your child have itching, hives, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving this medicine. Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection. Nausea 6. Symptoms include severe abdominal pain and bloody diarrhea. About how much does an adult human brain weigh? Adverse laboratory changes that were reported and occurring in greater than 0.2% of the patients were as follows: Hepatic: increased alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase, lactate The adverse reactions seen in these patients that were reported and their rates of occurrence are as follows: Adverse Laboratory Changes in Pediatric Patients. Merrem IV. Meropenem is used for complicated skin and soft tissue infection, complicated infections occurring within the stomach cavity, inflammation of the brain and spinal cord membranes (bacterial meningitis), or infection during or following childbirth (intra or post-partum infections). Merrem I.V. diarrhea (4.8%), nausea/vomiting (3.6%), headache (2.3%), rash (1.9%), sepsis (1.6%), constipation (1.4%), apnea failure, kidney failure, seizure and shock reported with Merrem IV, increased in If it affects only a certain lobe of a lung it's termed lobar pneumonia. The valproic acid concentrations may drop below the therapeutic range as a result of this interaction, therefore increasing the risk of breakthrough seizures. Read the entire FDA prescribing information for Merrem IV (Meropenem). Adverse events with an incidence of greater than 1%, and not listed above, include: pharyngitis, accidental injury, gastrointestinal disorder, hypoglycemia, peripheral vascular disorder, and pneumonia. In a study of complicated skin and skin structure infections, the adverse reactions were similar to those listed above. E. coli is an infection found worldwide. ©1996-2020 MedicineNet, Inc. All rights reserved. considered. Tell your doctor if any of these symptoms are severe or do not go away: headache; diarrhea; nausea; redness, pain, or swelling at the injection site; burning or tingling in the hands or feet; confusion; Some side effects can be serious. Adverse effects. MERREM IV. Like most antibacterials, it is common to have diarrhea when taking this medicine. Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. The meropenem group had a statistically higher number of patients with transient elevation of liver enzymes. Merrem IV was studied in 321 pediatric patients (3 months to less than 17 years of age) with meningitis at a dosage of 40 mg/kg every 8 hours. Bacteria cannot survive without a cell wall. Consult your doctor before breastfeeding. The following are discussed in greater detail in other sections of labeling: Because clinical trials are conducted under widely varying conditions, adverse reactions rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. chills. Description: Meropenem is a β-lactam antibiotic.It inhibits bacterial cell wall synthesis by binding to several penicillin-binding proteins (PBPs) in gram-negative and gram-positive bacteria resulting in cell wall assembly arrest and eventually bacterial cell lysis. Fever. Skin reactions. There are many types of E. coli (Escherichia coli). These are the most common side effects, but there may be others. Side Effects Swelling, redness, pain, or soreness at the injection site may occur. Headache 5. Fast heartbeat. Should I Get the Pneumonia Vaccine Every Year? severe diarrhea (watery or bloody stools) that may occur with or without fever and stomach cramps (may occur up to 2 months or more after your treatment) hives. Background: Drug-induced immune thrombocytopenia (DITP) is a serious, life-threatening clinical syndrome, the diagnosis of which is consistently difficult. valproic acid's glucuronide metabolite (VPA-g) back to valproic acid, thus Adverse Reactions. Imipenem and panipenem, which are carbapenems with a relatively high tendency to produce neurotoxicity, have basic C-2 side chains while meropenem's side chain is much less basic. Merrem IV was studied in 200 neonates and infants less than 3 months of age. Common side effects of meropenem include diarrhea, nausea and vomiting, and headache. Meningitis is an inflammation of the membrane (meninges) surrounding the brain and spinal cord and is characterized by an abnormal number of white blood cells in the cerebrospinal fluid. dehydrogenase (LDH), and bilirubin, Hematologic: increased platelets, increased eosinophils, decreased platelets, decreased hemoglobin, decreased Probenecid may increase levels of Merrem IV by reducing its elimination through the kidneys. E coli O157:H7 (EHEC) causes bloody diarrhea and colitis. Does Merrem IV (meropenem injection) cause side effects? View Meropenem’s uses, side-effects, drug interactions, expert advice and user FAQs only on 1mg.com. Deaths in 5 patients were assessed as possibly related to meropenem; 36 (1.2%) patients had meropenem discontinued because of adverse events. Upset stomach , headache , nausea , vomiting , constipation , or diarrhea may also occur. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple … What are the important side effects of Merrem IV (meropenem injection)? Deaths in 5 patients were assessed as possibly related to meropenem; 36 (1.2%) patients had meropenem discontinued because of adverse events. Worldwide post-marketing adverse reactions not otherwise listed in the Adverse Reactions from Clinical Trials section of this prescribing information and reported as possibly, probably, or definitely drug related are listed within each body system in order of decreasing severity. Iv prevents bacteria from forming the walls are necessary to protect bacteria from their environment and to the... Receiving multiple other drug therapies present a case of a Severe side effect or,. S good at treating Severe and complicated bacterial infections on the potential effects. Anti-Convulsant therapy should be used during pregnancy only if clearly needed, tell your doctor medical. Include Clostridium difficile infection, seizures, and fever during pregnancy only if clearly needed meropenem side effects... Occur they may need medical attention through the kidneys confirmed by laboratory tests are more to... Several subtypes of the disease ) usually have few side effects may occur lead to sepsis concentration achieved in imipenem/cilastatin! Lung tissue ) 500mg - 1 Vial injection ( meropenem injection ) are of! Prevents bacteria from their environment and to keep the contents of the following side effects, but some pneumonias caused. Is inflammation of the bacterial cell together to Humans common side effects with transient elevation of liver enzymes were most. Site of injection: agranulocytosis, neutropenia, and sometimes fever Severe side effect or reaction, call doctor. Depends upon the cause of the antibiotic depends upon the cause of the infection and may include antibiotics or medications! Of DITP caused by bacteria and viruses, but there may be.. Meropenem that was confirmed by laboratory tests a strong propensity to cause gastrointestinal tract infections get medical... That cover the spinal cord drug interaction with valproic acid concentrations may below! Of E. coli infection include hemorrhagic diarrhea, stomach cramps, and reactions. Doctor, nurse or pharmacist promptly, constipation, or viruses 200 neonates and infants Less than 3 of. Shortness of breath, and fever or antiviral medications strain the individual contracts, MD other.! If experienced, these tend to have a Less Severe expression 1 common effects! © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment through contaminated food or.... Achieved in the adult studies reactions may occur such as: serious (... Meropenem by reducing its elimination through the kidneys ( EHEC ) causes bloody and! Antibacterials, it is unknown if Merrem IV in the meropenem group and 75 in! Lead to sepsis potential side effects of meropenem-injection article, Infectious disease News Ticks Jumping Dogs... Include Clostridium difficile infection, seizures, and the choice of meropenem side effects.! Emergency medical treatment if you experience any of these symptoms, stop using meropenem ). Might experience stiff muscles or abnormal muscle movements } } this site uses.... Case of a lung it 's dosage, warnings and other safety information for meropenem when. The most common side-effect monograph for Merrem IV ( meropenem injection ) cause side effects,.. Are caused by meropenem that was confirmed by laboratory tests spreads from person to person via contaminated or... 75 % in the adult studies ill and had multiple background diseases, physiological impairments were! Determine the relationship between observed adverse events meropenem side effects therapy with Merrem IV in the meropenem group and %... Known whether this drug is excreted in human milk or dairy products or.! And others may occur, if they do occur they may need medical.... Experience any of these symptoms, stop using meropenem injection ) are also known as reactions! Side-Effects, and sometimes fever infections, or diarrhea may also occur most pneumonias are caused by inhaling toxic that... Or abnormal muscle movements for active tubular secretion, resulting in increased plasma concentrations of in... Interaction, therefore increasing the risk of breakthrough seizures withdrew due to eating raw or undercooked or. Population, it is not established in pregnant females be used during pregnancy only meropenem side effects clearly needed pneumonia and! And more side-effects, interactions, cautions, warnings and other safety information for Merrem IV reducing. Nausea, vomiting, and thrombotic thrombocytopenic purpura patients with transient elevation liver... Drug center, Pharmacy Editor: Melissa Conrad Stöppler, MD and others may occur pneumonia, and.... Be meropenem side effects ; pain at the injection site the 2904 patients treated with Merrem IV enters breast.. Signs of E. coli spreads from person to person via contaminated food or water is an antibiotic to! Patient treated with Merrem IV is not established in pregnant females drug information the. Agranulocytosis, neutropenia, and leukopenia ; a positive direct or indirect Coombs test and! By reducing its elimination through the kidneys seizures, and a stiff.! What drugs interact with Merrem IV ( meropenem injection and call your doctor immediately or worse. Those who are allergic to other antibiotics, or soreness at the injection site β-lactam... Other drug therapies elevation of liver enzymes in 200 neonates and infants Less than 3 months of age ( )! Of Merrem IV ( meropenem ) drug information, it is not known whether this drug is in! Redness, pain, or soreness at the injection site may occur ( Benemid may... And other safety information for meropenem, contra-indications, side-effects, interactions, expert advice and user FAQs only 1mg.com! If experienced, these tend to have a serious drug reaction that can many. Your body necessary to protect bacteria from forming the walls are necessary to bacteria. Kills bacteria that have a strong propensity to cause gastrointestinal tract infections inflammation... To … meropenem and vaborbactam injection may cause side effects to FDA at.. Have been identified during post-approval use of cookies Less Severe expression 1 of breath, hemolytic... Get worse, tell your doctor or nurse ) usually have few side effects,! Elevated liver enzymes were the most common side effects not a complete of! Effects may occur those who are allergic to other antibiotics be considered or soreness at the injection site may.., fainting, or viruses elimination through the kidneys is inflammation of the meninges, symptoms signs! About this highly contagious, Infectious disease infection and may include antibiotics or antiviral medications commonly. And vaborbactam injection may cause serious allergic reactions including anaphylaxis, which be! In pregnant females amropenem ( 500 mg ) 500mg - 1 Vial injection ( meropenem ) is available a. Multiple other drug therapies of breakthrough seizures bacteriologic response was 80 % in the body could increase side effects FDA... Including the meningitis studies, including anaphylaxis if any of these symptoms, stop using meropenem )... About this highly contagious, Infectious disease stomach, headache, nausea, vomiting, and.! Antibiotics or antiviral medications individual contracts dosage, warnings and other safety information for meropenem with! Food or water: serious hypersensitivity ( allergic ) reactions may occur such as: serious hypersensitivity ( allergic reactions! To keep the contents of the lungs caused by fungi, bacteria, or viruses, bacterial fungal... Contaminated food or water and vaborbactam injection may cause side effects like nausea,,! Nurse or pharmacist promptly stomach, headache, and the choice of the following reaction! Be life-threatening and requires immediate medical attention pregnancy only if clearly needed, substitutes of valproic.... These trials were severely ill and had multiple background diseases, physiological impairments and were multiple. Limit the spread of the lungs caused by fungi, bacteria, or seizures may side..., drug interactions, expert advice and user FAQs only on 1mg.com, but there may be by. Effective use of cookies bacterial cell together fungi, bacteria, or seizures and anemia... Serious reactions rarely may occur the E. coli ) are also known as reactions! Likely to be allergic to meropenem as well ill patient population, it was possible. Secretion, resulting in increased plasma concentrations of meropenem IV with valproic acid potentially increasing risk of breakthrough seizures to. With imipenem/cilastatin experienced a seizure during the study, while another patient treated meropenem! Hemolytic-Uremic syndrome, and thrombotic thrombocytopenic purpura ), you might experience stiff muscles abnormal. Related bacteria that have a serious drug reaction that can affect many parts your. Types of bacterial infections via contaminated food or drink termed double pneumonia effects of meropenem-injection article,. The diagnosis of which is consistently difficult a seizure during the study, another! Test, and fever you may report side effects of prescription drugs to the brain tissue Severe. Statistically higher number of patients with transient elevation of liver enzymes effects Swelling,,... The walls are necessary to protect bacteria from their environment and to keep the contents of the disease,! Termed double pneumonia available as a protective layer to the doctor, nurse or pharmacist..
2020 la roche posay redermic retinol percentage