The histopathology, IHC, and quantitative RT-PCR results from both sheep and goats also provide some insight into the disease progression of PPR in small ruminants. However, the total picture is rather distinctive. Presumptive diagnosis of the disease was done on the basis of history, clinical signs, mortality pattern, postmortem and histopathological findin gs. PPR is a disease of high morbidity and mortality that affect small ruminants reared by poor and marginal farmers of India. Laboratory diagnosis of PPR a. In fact, the incipient stages of ARDS can create a picture of pulmonary edema similar to HPS. PubMed Peste des petits ruminants (PPR) is an acute to sub-acute highly contagious and frequently fatal viral disease of goats and sheep and wild small ruminants caused by a virus in the genus morbilivirus, family paramyxoviridae. • They not only establish tissue diagnosis, but are crucial in clinical management & provide important prognostic data. PLoS One 9:e87145. Downloadable! Vet Microbiol 197:137–141. The pathology department also proudly owns an ultra-modern recently upgraded blood bank with modern technology and equipped with blood component facilities. Further molecular examination showed that the virus belongs to the Asian clade of lineage IV and is closely related to a virus described in Turkey. immunoperoxidase) is then performed with focus on detection of multinucleated giant cells. Recognition of PPR as a problem has increased in the 1990s, partly as a result of surveillance activities of the global rinderpest eradication programme (GREP), but also because of the capacity of the infection to invade disease-free countries. Histology revealed necrohemorrhagic enteritis and abomasitis with myriad nuclear and cytoplasmic viral inclusion bodies. CAS … It is good practice to collect blood for serological diagnosis at all stages, but particularly later in the outbreak. https://doi.org/10.1016/S0921-4488(97)00095-3. It was first reported in Cote d’Ivoire (the Ivory Coast) in 1942 and subsequently in other parts of West Africa. Peste des petits ruminants (PPR) is a devastating disease that generally affects sheep and goats, mostly in Asia, the Middle East and Africa. Confirmatory tests include histopathology, polymerase chain reaction (PCR), virus isolation (VI), and virus neutralization (VN). Confirmatory tests include histopathology, polymerase chain reaction (PCR), virus isolation (VI), and virus neutralization (VN). In the regions where PPR occurs in an epizootic form it may have dramatic consequences for animal owners due to high mortality rates. INTRODUCTION Peste des petits ruminants (PPR), is an acute, highly contagious and economically important transboundary viral disease of sheep and goats associated with high morbidity and mortality (Balamurugan et al., 2014). Results: … Immediate online access to all issues from 2019. Following the first description of PPR it was postulated that the causal agent was a variant strain of rinderpest adapted to small ruminants (Mornet et al., 1956).This was confirmed by the present knowledge on the epidemiology of the two diseases which occur separately … https://doi.org/10.1099/vir.0.025841-0, Article 14. Author(s) : ... see more details, histopathology histopathology Subject Category: Disciplines, Occupations and Industries see more details, postmortem examinations postmortem examinations Subject Category: Techniques, Methodologies and Equipment Histopathology combined with immunohistochemical staining (e.g. In both species, significant levels of virus were detected in the lymph nodes, lymphoid tissues and digestive tract at 6 dpi. Animal Front 4:14–20, Kinne J, Kreutzer R, Kreutzer M, Wernery U, Wohlsein P (2017) Peste des petits ruminants in Arabian wildlife. A tentative diagnosis of PPR can be made based on clinical signs, but this ... • Set of tissues for histopathology should be placed in 10% neutral buffered formalin PubMed Central https://doi.org/10.1016/j.vetmic.2016.11.006, http://www.oie.int/fr/sante-animale-dans-le-monde/portail-ppr/, https://doi.org/10.1371/journal.pone.0087145, https://doi.org/10.1111/j.1865-1682.2011.01270.x, https://doi.org/10.1007/s00705-017-3456-4, https://doi.org/10.1007/s00705-019-04269-y. It is closely related to Rinderpest, measles, canine distemper and morbilliviruses of marine mammals and is the most economically important viral disease of small ruminants [1-3]. Peste des petits ruminants (PPR) is an acute or subacute viral disease of goats and sheep characterized by fever, necrotic stomatitis, gastroenteritis, pneumonia, and sometimes death. Histopathology is an international journal intended to be of practical value to surgical and diagnostic histopathologists, and to investigators of human disease who employ histopathological methods. Department has modern histopathology, cytopathology, haematology and service laboratories for catering the needs of Mahatma Gandhi Hospital attached to the medical college. The flock of sheep including 800 fattening sheep were affected and the presence of PPR virus was assayed with RT-PCR test. PPR infection is most commonly recorded among the sheep population in India. OVERVIEW OF HISTOPATHOLOGYBYSEEMA DEROTRANIEE TECHNOLOGIST 2. The disease has been declared a target for global eradication. J Gen Virol 91:2885–2897. Histopathology. Author information: (1)Department of Radiology, University of Cambridge, Cambridge, United Kingdom. At the end of the outbreak, blood can be collected for serological diagnosis. PubMed Arch Virol 162:3157–3160. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Histopathology of natural cases of PPR, characteristics, lesions and changes occurring during the disease. Since then, other attempts to reproduce the pathology associated with PPR have been performed under experimental conditions [13–16], however, results have varied considerably.
2020 histopathology of ppr