{"id":304710,"date":"2021-05-26T17:34:53","date_gmt":"2021-05-27T00:34:53","guid":{"rendered":"https:\/\/icitynews.com\/?p=304710"},"modified":"2021-05-26T17:34:53","modified_gmt":"2021-05-27T00:34:53","slug":"city-of-hope-%e5%85%92%e7%a7%91%e8%85%a6%e8%85%ab%e7%98%a4-car-t-%e7%b4%b0%e8%83%9e%e8%a9%a6%e9%a9%97%e7%8d%b2%e5%be%97840%e8%90%ac%e7%be%8e%e5%85%83%e6%92%a5%e6%ac%be","status":"publish","type":"post","link":"https:\/\/icitynews.com\/?p=304710","title":{"rendered":"City of Hope \u5152\u79d1\u8166\u816b\u7624 CAR T \u7d30\u80de\u8a66\u9a57\u7372\u5f97840\u842c\u7f8e\u5143\u64a5\u6b3e"},"content":{"rendered":"

\u7531 City of Hope Leo Wang \u91ab\u751f\u8207\u91ab\u5b78\u535a\u58eb\u9818\u5c0e\u7684\u7814\u7a76\u4eba\u54e1\uff0c\u6b63\u8abf\u67e5\u7814\u7a76\u4e00\u7a2e\u5275\u65b0\u7642\u6cd5\uff0c\u4ee5\u5c0d\u6297\u5e7c\u7ae5\u56e0\u764c\u75c7\u800c\u81f4\u547d\u6700\u5e38\u898b\u6210\u56e0\u3002<\/p>\n

\u52a0\u5dde\u675c\u963f\u723e\u7279\u8a0a (DUARTE,California) \u2014 \u8209\u4e16\u805e\u540d\u7684\u764c\u75c7\u3001\u7cd6\u5c3f\u75c5\u53ca\u5176\u5b83\u81f4\u547d\u75be\u75c5\u7368\u7acb\u7814\u7a76\u8207\u6cbb\u7642\u4e2d\u5fc3 City of Hope \u4eca\u5929\u9686\u91cd\u5ba3\u5e03\uff0c\u7531City of Hope Leo Wang \u91ab\u751f\u8207\u91ab\u5b78\u535a\u58eb (M.D., Ph.D.) \u9818\u5c0e\u7684\u5be6\u9a57\u5ba4\uff0c\u7372\u5f97California Institute for Regenerative Medicine (\u52a0\u5dde\u518d\u751f\u85e5\u7269\u5b78\u9662) \u6388\u4e88840\u842c\u7f8e\u5143\u64a5\u6b3e\uff0c\u4ee5\u9032\u884c\u7814\u7a76\u5d4c\u5408\u6297\u539f\u53d7\u9ad4 (chimeric antigen receptor [CAR]) T
\n\u7d30\u80de\u7642\u6cd5\uff0c\u6cbb\u7642\u5152\u79d1\u8166\u816b\u7624\u3002<\/p>\n

\u5152\u79d1\u8166\u816b\u7624\u662f\u6700\u5e38\u898b\u7684\u5152\u7ae5\u5be6\u8cea\u56fa\u614b\u816b\u7624\uff0c\u4e5f\u662f\u5e7c\u7ae5\u56e0\u764c\u75c7\u800c\u81f4\u547d\u7684\u6700\u5e38\u898b\u6210\u56e0\u3002\u96d6\u7136\u4e00\u4e9b\u8166\u816b\u7624\u5df2\u6709\u6709\u6548\u7642\u6cd5\uff0c\u4f46\u4ecd\u6709\u5176\u5b83\u96e3\u65bc\u6cbb\u7642\u7684\u8166\u816b\u7624\uff0c\u4f8b\u5982\u64f4\u6563\u578b\u5167\u56e0\u6027\u8166\u6a4b\u795e\u7d93\u81a0\u8cea\u7624 (diffuse intrinsic pontine glioma) \u7b49\u8f03\u51f6\u96aa\u7684\u60e1\u6027\u816b\u7624\uff0c\u78ba\u8a3a\u5f8c\u7684\u5b58\u6d3b\u7387\u4e2d\u4f4d\u6578\u70ba9 \u81f315 \u500b\u6708\u3002<\/p>\n

\"\"<\/p>\n

Leo Wang \u91ab\u751f\u8207\u91ab\u5b78\u535a\u58eb\u662fCity of Hope \u7684\u5152\u79d1\u8840\u6db2\u75c5\u79d1\u5c08\u5bb6\u517c\u816b\u7624\u79d1\u5c08\u5bb6\uff0c\u4ed6\u4e5f\u662f\u6b64\u9805\u5168\u65b0\u7b2c\u4e00\u671f\u8a66\u9a57 (Phase 1 trial) \u8abf\u67e5\u7814\u7a76\u7684\u9805\u76ee\u8ca0\u8cac\u4eba\uff1b\u8a72\u9805\u8abf\u67e5\u7814\u7a76\u9805\u76ee\u516c\u958b\u63a5\u53d74 \u5230 25\u6b72\u3001\u8166\u816b\u7624\u5448\u73fe\u4e00\u7a2e\u5728\u7d04\u534a\u6578\u5152\u79d1\u8166\u816b\u7624\u4e2d\u627e\u5230\uff0c\u540d\u70ba\u767d\u7d30\u80de\u4ecb\u7d20 \u2013 13\u53d7\u9ad4\u6b21\u55ae\u5143alpha-2 (interleukin-13 receptor subunit alpha-2 [IL-13Ra2]) \u6297\u539f\u7684\u75c5\u60a3\u3002<\/p>\n

\u4ed6\u8868\u793a\uff1a\u300cCity of Hope \u4e00\u76f4\u662f\u958b\u5c55CAR T \u7d30\u80de\u7642\u6cd5\u7684\u5148\u92d2\u3002\u6211\u975e\u5e38\u8208\u596e\u80fd\u5920\u70ba\u9019\u4e9b\u5152\u7ae5\u63a1\u7528\u6b64\u6df1\u5177\u524d\u666f\u7684\u7642\u6cd5\u3002\u300d<\/p>\n

CAR T \u7d30\u80de\u7642\u6cd5\u6539\u9020\u4e86T \u7d30\u80de \u2014 \u5728\u6b64\u7814\u7a76\u4e2d\uff0c\u75c5\u60a3\u81ea\u5df1\u7684T \u7d30\u80de \u2014 \u4f86\u5c0d\u6297\u7279\u5b9a\u7684\u764c\u7d30\u80de\u3002\u76ee\u524d\uff0c\u6709\u591a\u9805
\nCAR T \u7d30\u80de\u7642\u6cd5\u5df2\u7372\u7f8e\u570b\u98df\u7269\u53ca\u85e5\u54c1\u7ba1\u7406\u5c40 (Food and Drug Administration) \u6279\u51c6\u6cbb\u7642\u591a\u7a2e\u8840\u764c\uff0c\u4e26\u5c0d\u5be6\u8cea\u56fa\u614b\u816b\u7624\u6709\u986f\u8457\u7642\u6548\u3002<\/p>\n

CAR T \u7d30\u80de\u7642\u6cd5\u5148\u5f9e\u4e00\u500b\u540d\u70ba\u767d\u7d30\u80de\u5206\u96e2\u8853 (leukapheresis) \u7684\u904e\u7a0b\u958b\u59cb\uff0c\u5206\u958b\u4e26\u6536\u96c6\u767d\u8840\u7403\u7d30\u80de\uff0c\u4ee5\u4fbf\u7372\u5f97\u7d30\u80de\u5167\u7684T \u7d30\u80de\u3002\u9019\u4e9bT \u7d30\u80de\u88ab\u6539\u9020\u5f8c\u80fd\u5920\u78ba\u8a8d\u816b\u7624\u6297\u539f (\u5728\u6b64\u5373\u6307IL-13Ra2) \uff0c\u7136\u5f8c\u5728\u5be6\u9a57\u5ba4\u57f9\u80b2\u53ca\u7e41\u6b96\u3002\u7d93\u904e\u56b4\u683c\u7684\u88fd\u9020\u548c\u54c1\u7ba1\u904e\u7a0b\u5f8c\uff0c\u7d30\u80de\u6703\u88ab\u7cbe\u6e96\u7d30\u5fc3\u5730\u9810\u5099\u597d\uff0c\u518d\u9001\u905e\u4e88\u6e96\u5099\u63a5\u53d7\u6ce8\u5165CAR T \u7d30\u80de\u7684\u75c5\u60a3\u3002<\/p>\n

\u5c0d\u8840\u764c\u75c5\u60a3\u800c\u8a00\uff0c\u5148\u63a5\u53d7\u6e05\u9664\u6dcb\u5df4\u7d30\u80de\u5316\u7642 (lymphodepleting chemotherapy)\uff0c\u6703\u8b93CAR T \u7d30\u80de\u7642\u6cd5\u6700\u6709\u6210\u6548\u3002\u6b64\u65b9\u6cd5\u80fd\u964d\u4f4e\u8840\u6db2\u5167\u767d\u7d30\u80de\u6578\u91cf\uff0c\u63d0\u4f9b\u66f4\u591a\u7a7a\u9593\u8b93CAR T \u7d30\u80de\u64f4\u5c55\u3002City of Hope \u7684\u8a66\u9a57\u5c07\u6703\u662f\u5c0d\u5152\u79d1\u8166\u816b\u7624\u9032\u884cCAR T \u7d30\u80de\u6e2c\u8a66\u7684\u9996\u9805\u8a66\u9a57\uff1b\u9452\u65bc\u9019\u662f\u91dd\u5c0d\u5152\u7ae5\u7684\u65b0\u7a4e\u7642\u6cd5\uff0c\u9996\u4e09\u540d\u8a66\u9a57\u5c0d\u8c61\u5c07\u53ea\u63a5\u53d7CAR T \u7d30\u80de\u7642\u6cd5\u3002\u6e05\u9664\u6dcb\u5df4\u7d30\u80de\u5316\u7642 (lymphodepleting chemotherapy) \u5247\u6703\u7531\u7b2c\u56db\u540d\u75c5\u60a3\u958b\u59cb\u3002<\/p>\n

\u6b64\u5916\uff0c\u9019\u8a66\u9a57\u5c07\u6703\u63a1\u7528\u7531City of Hope T \u7d30\u80de\u6cbb\u7642\u5b78\u7814\u7a76\u5be6\u9a57\u5ba4 (T Cell Therapeutics Research Laboratory) \u526f\u6240\u9577\u517cHeritage Provider Network (\u50b3\u7d71\u91ab\u7642\u670d\u52d9\u63d0\u4f9b\u8005\u7db2\u7d61) \u514d\u75ab\u6cbb\u7642\u6559\u6388Christine Brown \u535a\u58eb (Ph.D.) \u8207\u795e\u7d93\u5916\u79d1\u91ab\u751f\u517cCity of Hope \u5916\u79d1\u90e8\u8166\u816b\u7624\u79d1\u8a08\u5283\u4e3b\u4efbBehnam Badie (M.D.) \u5171\u540c\u59cb\u5275\u7684\u5275\u65b0\u905e\u9001\u65b9\u6cd5\u3002\u53c3\u8207\u8a66\u9a57\u7684\u75c5\u60a3\u5c07\u63a5\u53d7\u6700\u591a\u56db\u6b21\u6ce8\u5c04\u3002<\/p>\n

\u300cCAR T \u7d30\u80de\u7642\u6cd5\u4e00\u822c\u901a\u904e\u975c\u8108\u8f38\u5165\uff0c\u7136\u5f8c\u7d30\u80de\u900f\u904e\u96a8\u8457\u8840\u6db2\u6d41\u52d5\u627e\u5230\u816b\u7624\u3002\u4f46\u8166\u8840\u7ba1\u969c\u58c1\u5206\u9694\u4e86\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u5faa\u74b0\u7684\u8840\u6db2 \uff0c\u5c0e\u81f4CAR T \u7d30\u80de\u9032\u5165\u8166\u90e8\u6709\u96e3\u5ea6\u3002\u300dLeo Wang \u91ab\u751f\u8207\u91ab\u5b78\u535a\u58eb\u89e3\u91cb\u3002\u300c\u5728\u6b64\u8a66\u9a57\u4e2d\uff0c\u6211\u5011\u5c07CAR T \u7d30\u80de\u76f4\u63a5\u5f15\u5c0e\u5230\u8166\u5ba4\uff0c\u4f7f\u5176\u5c0d\u8166\u816b\u7624\u66f4\u70ba\u6709\u6548\u3002\u4e8b\u5be6\u4e0a\uff0c\u8a31\u591a\u5176\u4ed6\u6a5f\u69cb\u4ea6\u958b\u59cb\u63a1\u7d0d\u6b64\u65b9\u6cd5\u3002\u300d<\/p>\n

Leo Wang \u91ab\u751f\u8207\u91ab\u5b78\u535a\u58eb\u65bc2016\u5e74\u958b\u59cb\u5728City of Hope\u5de5\u4f5c\uff0c\u4e00\u76f4\u671f\u671bCAR T \u7d30\u80de\u8a08\u5283\u53ef\u4ee5\u70ba\u5152\u79d1\u8166\u764c\u958b\u5c55\u4e00\u500b\u8a66\u9a57\u9805\u76ee\u3002\u5168\u8cf4\u8a66\u9a57\u9805\u76ee\u5718\u968a\u7684\u5168\u5fc3\u4ed8\u51fa\uff0c\u8a66\u9a57\u9805\u76ee\u7d42\u65bc\u63da\u5e06\u555f\u822a\u3002<\/p>\n

\u300c\u4e00\u7fa4\u512a\u7570\u7684\u4eba\u58eb\u5b5c\u5b5c\u4e0d\u5026\u3001\u52aa\u529b\u4e0d\u61c8\u8b93\u6b64\u8a66\u9a57\u5f97\u4ee5\u843d\u5be6\uff0c\u7576\u4e2d\u5305\u62ec\u4e86\u79d1\u5b78\u5bb6\u3001\u91ab\u7642\u670d\u52d9\u63d0\u4f9b\u8005\u3001\u7d93\u7406\u3001\u76e3\u7ba1\u53ca\u71df\u904b\u90e8\u9580\u540c\u4e8b\u3001\u8cc7\u91d1\u7c4c\u52df\u8005\u7b49\u7b49\uff0c\u300dLeo Wang \u91ab\u751f\u8207\u91ab\u5b78\u535a\u58eb\u88dc\u5145\u8aaa\u3002\u300c\u6211\u6df1\u611f\u69ae\u5e78\u80fd\u5920\u6210\u70ba\u9019\u8a66\u9a57\u5718\u968a\u4e4b\u4e00\u54e1\uff0c\u80fd\u5920\u6bcf\u5929\u53c3\u8207\u6b64\u9805\u76ee\u66f4\u662f\u8207\u6709\u69ae\u7109\u3002\u300d<\/p>\n

\u6709\u8208\u8da3\u53c3\u8207\u6b64\u8a66\u9a57\u7684\u4eba\u58eb\u53ef\u4ee5\u81f4\u96fb833-582-HOPE (4673)\u00a0\u6216\u96fb\u90f5\u00a0PediatricTrials@coh.org \u4e86\u89e3\u66f4\u591a\u8a73\u60c5\u3002<\/p>\n

\u672a\u7ecf\u5141\u8bb8\u4e0d\u5f97\u8f6c\u8f7d\uff1a\u57ce\u5e02\u65b0\u95fb\u7f51icitynews<\/a> » City of Hope \u5152\u79d1\u8166\u816b\u7624 CAR T \u7d30\u80de\u8a66\u9a57\u7372\u5f97840\u842c\u7f8e\u5143\u64a5\u6b3e<\/a><\/p>","protected":false},"excerpt":{"rendered":"

\u7531 City of Hope Leo Wang \u91ab\u751f\u8207\u91ab\u5b78\u535a\u58eb\u9818\u5c0e\u7684\u7814\u7a76\u4eba\u54e1\uff0c\u6b63\u8abf\u67e5\u7814\u7a76\u4e00\u7a2e\u5275\u65b0\u7642\u6cd5\uff0c\u4ee5\u5c0d\u6297\u5e7c\u7ae5\u56e0\u764c\u75c7\u800c\u81f4\u547d\u6700\u5e38\u898b\u6210\u56e0\u3002 \u52a0\u5dde\u675c\u963f\u723e\u7279\u8a0a (DUARTE,California) \u2014 \u8209 […]<\/p>\n","protected":false},"author":29,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[9],"tags":[],"class_list":["post-304710","post","type-post","status-publish","format-standard","hentry","category-la_local_news"],"_links":{"self":[{"href":"https:\/\/icitynews.com\/index.php?rest_route=\/wp\/v2\/posts\/304710","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/icitynews.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/icitynews.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/icitynews.com\/index.php?rest_route=\/wp\/v2\/users\/29"}],"replies":[{"embeddable":true,"href":"https:\/\/icitynews.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=304710"}],"version-history":[{"count":0,"href":"https:\/\/icitynews.com\/index.php?rest_route=\/wp\/v2\/posts\/304710\/revisions"}],"wp:attachment":[{"href":"https:\/\/icitynews.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=304710"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/icitynews.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=304710"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/icitynews.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=304710"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}