2019\u5e743\u67085\u65e5<\/p>\n
\u4e16\u754c\u9876\u7ea7\u533b\u5b66\u6742\u5fd7\u300a\u81ea\u7136\u300b(Nature)<\/p>\n
\u520a\u767b\u7684\u4e00\u7bc7\u62a5\u9053<\/p>\n
\u8ba9\u5168\u7403\u4eba\u6c11\u4e3a\u4e4b\u6cb8\u817e\uff1a<\/p>\n
\u5728\u4f26\u6566<\/p>\n
\u4e00\u540d\u827e\u6ecb\u75c5+\u764c\u75c7\u53cc\u91cd\u75be\u75c5\u60a3\u8005\u7684\u827e\u6ecb\u75c5\u75c5\u6bd2(HIV)<\/p>\n
\u7ecf\u8fc7\u9aa8\u9ad3\u5e72\u7ec6\u80de\u79fb\u690d\u624b\u672f\u540e<\/p>\n
\u51fa\u73b0\u4e86\u660e\u663e\u7684\u7f13\u89e3\u75c7\u72b6<\/p>\n
\u533b\u5b66\u754c\u76ee\u524d\u5c06\u8fd9\u4f4d\u60a3\u8005\u6210\u4e3a\u201c\u4f26\u6566\u75c5\u4eba\u201d<\/p>\n
\u8fd9\u540d\u6765\u81ea\u4f26\u6566\u7684\u60a3\u8005\u4f53\u5185\u7684HIV\u75c5\u6bd2<\/p>\n
\u5728\u63a5\u53d7\u5e72\u7ec6\u80de\u79fb\u690d\u540e<\/p>\n
\u8fde\u7eed\u505c\u836f19\u4e2a\u6708<\/p>\n
\u800c\u75c5\u60c5\u5374\u4f9d\u7136\u5f97\u5230\u7f13\u89e3<\/p>\n
\u56fd\u9645\u827e\u6ecb\u75c5\u534f\u4f1a(International AIDS Society)<\/p>\n
\u5728\u4e00\u4efd\u58f0\u660e\u4e2d\u8868\u793a<\/p>\n
\u76ee\u524d\u8fd9\u4e00\u6210\u679c\u8fd8\u4e0d\u80fd\u88ab\u5b9a\u4e49\u4e3a\u4e00\u79cd\u7597\u6cd5<\/p>\n
\u4e5f\u4e0d\u80fd\u5c31\u6b64\u8ba4\u5b9a\u827e\u6ecb\u75c5\u5df2\u7ecf\u88ab\u5f7b\u5e95\u653b\u514b<\/p>\n
\u4f46\u8fd9\u4f4d\u75c5\u4eba\u8eab\u4e0a\u51fa\u73b0\u7684HIV\u75c5\u6bd2\u7684\u201c\u957f\u671f\u7f13\u89e3\u201d<\/p>\n
\u5df2\u7ecf\u662f\u533b\u5b66\u4e8b\u5b9e<\/p>\n
\u57283\u67084\u65e5\u81f37\u65e5\u5728\u7f8e\u56fd\u897f\u96c5\u56fe\u4e3e\u884c\u7684<\/p>\n
\u9006\u8f6c\u5f55\u75c5\u6bd2\u548c\u673a\u4f1a\u6027\u611f\u67d3\u4f1a\u8bae\u4e0a<\/p>\n
\uff08annual Conference on Retroviruses and Opportunistic Infections\uff09<\/p>\n
\u4eba\u4eec\u5c06\u89c1\u8bc1\u8fd9\u9879\u6cbb\u7597\u7684\u9886\u5bfc\u8005<\/p>\n
\u6765\u81ea\u4f26\u6566\u5927\u5b66\u5b66\u9662\u7684\u75c5\u6bd2\u5b66\u5bb6<\/p>\n
\u53e4\u666e\u5854\u6559\u6388\uff08Ravindra Gupta\uff09<\/p>\n
\u5411\u5927\u5bb6\u4ecb\u7ecd\u8fd9\u4e00\u4ee4\u4e16\u754c\u77a9\u76ee\u7684\u6210\u679c<\/p>\n
\u70b9\u51fb\u67e5\u770b\u5927\u56fe<\/p>\n
\u81ea\u4ece\u533b\u5b66\u754c\u57281981\u5e74\u9996\u6b21\u5728\u7f8e\u56fd<\/p>\n
\u53d1\u73b0HIV\u75c5\u6bd2\u540e<\/p>\n
38\u5e74\u7684\u65f6\u95f4\u91cc<\/p>\n
\u653b\u514bHIV\u88ab\u8ba4\u4e3a\u662f\u4e16\u754c\u533b\u5b66\u754c\u7684\u5934\u53f7\u96be\u9898\u4e4b\u4e00<\/p>\n
\u800c\u5728\u8fd9\u6f2b\u957f\u768438\u5e74\u65f6\u95f4\u91cc<\/p>\n
\u88abHIV\u611f\u67d3\u7684\u7fa4\u4f53\u4e5f\u65e5\u6e10\u5e9e\u5927<\/p>\n
\u5df2\u7ecf\u8fbe\u5230\u8fd13700\u4e07\u4eba<\/p>\n
\u7b2c\u4e8c\u4f8b\u827e\u6ecb\u75c5\u4eba\u75c5\u60c5\u7f13\u89e3\u7684\u6d88\u606f<\/p>\n
\u6beb\u65e0\u7591\u95ee\u77ac\u95f4\u71c3\u70b9\u4e86\u5168\u74033700\u4e07\u827e\u6ecb\u75c5\u4eba<\/p>\n
\u5bf9\u4e8e\u751f\u547d\u7684\u6e34\u671b<\/p>\n
\u300a\u7ebd\u7ea6\u65f6\u62a5\u300b<\/p>\n
\u300a\u534e\u76db\u987f\u90ae\u62a5\u300b<\/p>\n
\u300a\u4eca\u65e5\u7f8e\u56fd\u300b<\/p>\n
bloomberg<\/p>\n
\u5404\u5927\u4e3b\u6d41\u7eb7\u7eb7\u5c06\u8fd9\u4e00\u666e\u5927\u559c\u5954\u7684\u597d\u6d88\u606f\u63a8\u4e0a\u5934\u6761<\/p>\n
\u79f0\u8fd9\u4e00\u5947\u8ff9\u6216\u8bc1\u660e\u827e\u6ecb\u75c5\u7ec8\u5c06\u53ef\u4ee5\u88ab\u6cbb\u6108<\/p>\n
\u800c\u8fd9\u4f4d\u201c\u4f26\u6566\u60a3\u8005\u201d\u6b64\u6b21\u4e3a\u4e16\u754c\u5e26\u6765\u7684\u798f\u97f3<\/p>\n
\u8ddd\u79bb\u7b2c\u4e00\u6b21\u4ece\u201c\u67cf\u6797\u75c5\u4eba\u201d\u8eab\u4e0a<\/p>\n
\u542c\u5230\u827e\u6ecb\u75c5\u6bd2\u88ab\u6cbb\u6108\u7684\u6d88\u606f<\/p>\n
\u5df2\u7ecf\u8fc7\u53bb\u4e8612\u5e74<\/p>\n
\u662f\u7684\uff0c12\u5e74\u4e86<\/p>\n
\u5168\u7403\u7b2c\u4e00\u4f4d\u827e\u6ecb\u75c5\u6210\u529f\u6cbb\u6108\u8005<\/p>\n
\u4f9d\u7136\u5065\u5eb7\u7684\u5728\u8fd9\u4e2a\u4e16\u754c\u611f\u53d7\u7740\u9633\u5149\u7684\u6e29\u6696<\/p>\n
\u5728\u7ed9\u4e16\u754c\u5e26\u6765\u7b2c\u4e00\u7f15\u5e0c\u671b\u7684\u66d9\u5149\u524d<\/p>\n
\u8fd9\u4f4d\u5168\u7403\u9996\u4f8b\u827e\u6ecb\u75c5\u6210\u529f\u88ab\u6cbb\u6108\u60a3\u8005<\/p>\n
\u8482\u83ab\u897f\u00b7\u5e03\u6717(Timothy Brown)<\/p>\n
\u66fe\u6d3b\u5728\u65e0\u5c3d\u7684\u9ed1\u6697\u4e2d<\/p>\n
\u8eab\u53d7\u827e\u6ecb\u75c5\u548c\u764c\u75c7\u53cc\u91cd\u6298\u78e8\u7684\u60a3\u8005<\/p>\n
Timothy\u6210\u957f\u4e8e\u7f8e\u56fd\u897f\u96c5\u56fe<\/p>\n
1991\u5e74\u642c\u5230\u5fb7\u56fd\u67cf\u6797\u5c45\u4f4f\u7684\u4ed6<\/p>\n
\u5728\u4ea4\u5f80\u4e86\u51e0\u4efb\u540c\u6027\u604b\u7537\u53cb\u540e<\/p>\n
\u4e0d\u5e78\u57281995\u5e74\u88ab\u786e\u8bca\u611f\u67d3\u827e\u6ecb\u75c5<\/p>\n
\u5728\u8eab\u5fc3\u75db\u82e6\u4e2d\u88ab\u6467\u6b8b\u4e00\u5e74\u7684Timothy<\/p>\n
\u4e8e1996\u5e74\u770b\u5230\u4e86\u751f\u6d3b\u7ed9\u4ed6\u7684\u4e00\u4e1d\u5e0c\u671b<\/p>\n
\u90a3\u5c31\u662f1996\u5e74\u75c5\u6bd2\u7597\u6cd5\uff08ART\uff09\u7684\u8bde\u751f<\/p>\n
\u4f7f\u5f97\u827e\u6ecb\u75c5\u6210\u4e3a\u53ef\u63a7\u6027\u6162\u6027\u75be\u75c5<\/p>\n
\u5728\u575a\u6301\u670d\u836f\u7684\u60c5\u51b5\u4e0b<\/p>\n
\u751f\u547d\u53ef\u4ee5\u5f97\u5230\u6700\u5927\u9650\u5ea6\u7684\u5ef6\u7eed<\/p>\n
Timothy\u5c31\u8fd9\u6837\u4e0e\u827e\u6ecb\u75c5\u6bd2\u4e3a\u4f34<\/p>\n
\u751f\u6d3b\u4e8610\u5e74<\/p>\n
\u6216\u8bb8\u662f\u751f\u6d3b\u770b\u4ed6\u8fc7\u7684\u592a\u8fc7\u4e8e\u5e73\u9759\u4e86<\/p>\n
\u53c8\u548c\u4ed6\u5f00\u4e86\u4e00\u6b21\u73a9\u7b11<\/p>\n
2006\u5e74\uff0cTimothy\u53c8\u88ab\u786e\u8bca\u4e3a<\/p>\n
\u6025\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5<\/p>\n
\u6b63\u5f53Timothy\u518d\u6b21\u89c9\u5f97\u81ea\u5df1\u5760\u5165\u6df1\u6e0a\u65f6<\/p>\n
\u547d\u8fd0\u518d\u4e00\u6b21\u4eb2\u543b\u4e86\u4ed6<\/p>\n
Timothy\u5728\u6cbb\u7597\u767d\u8840\u75c5\u671f\u95f4<\/p>\n
\u9047\u5230\u4e86GeroH\u00fctter\u533b\u751f<\/p>\n
\u4ed6\u51b3\u5b9a\u4e3aTimothy\u5b9e\u65bd\u9aa8\u9ad3\u5e72\u7ec6\u80de\u79fb\u690d\u624b\u672f<\/p>\n
\uff08 stem-cell treatment \uff09<\/p>\n
\u8003\u8651\u5230Timothy\u540c\u65f6\u8eab\u60a3\u827e\u6ecb\u75c5\u7684\u72b6\u51b5<\/p>\n
\u5728267\u4e2a\u4e0eTimothy\u914d\u5bf9\u6210\u529f\u7684\u8840\u6db2\u6837\u672c\u4e2d<\/p>\n
GeroH\u00fctter\u5bfb\u627e\u5230\u4e86\u4e00\u4f4d<\/p>\n
\u5177\u6709\u827e\u6ecb\u75c5\u62b5\u6297\u529b\u7684\u6350\u732e\u8005<\/p>\n
\u5c06\u6b64\u4eba\u7684\u9aa8\u9ad3\u4e3aTimothy\u505a\u4e86\u79fb\u690d<\/p>\n
2007\u5e745\u6708<\/p>\n
\u5728Timothy\u63a5\u53d7\u9aa8\u9ad3\u79fb\u690d\u624b\u672f\u76843\u4e2a\u6708\u540e<\/p>\n
\u4ed6\u8840\u6db2\u5185\u7684HIV\u75c5\u6bd2\u5728\u68c0\u6d4b\u65f6\u5448\u73b0\u9634\u6027<\/p>\n
\u4ed6\u4e5f\u4e8e2007\u5e749\u6708\u5f00\u59cb<\/p>\n
\u6b63\u5f0f\u505c\u7528\u827e\u6ecb\u75c5\u6cbb\u7597\u836f\u7269<\/p>\n
\u6b64\u65f6\u8fd8\u6709\u53e6\u4e00\u5904\u53cd\u8f6c\u5267\u60c5\u5c1a\u672a\u4e0a\u6f14<\/p>\n
2008\u5e742\u6708<\/p>\n
Timothy\u5728\u767d\u8840\u75c5\u590d\u53d1\u540e<\/p>\n
\u7b2c2\u6b21\u63a5\u53d7\u9aa8\u9ad3\u79fb\u690d\u624b\u672f\u7684\u6cbb\u7597<\/p>\n
\u8fd9\u6b21\u624b\u672f\u4e0d\u4ec5\u8ba9\u4ed6\u7684\u767d\u8840\u75c5\u4ece\u6b64\u9500\u58f0\u533f\u8ff9<\/p>\n
\u68c0\u6d4b\u7ed3\u679c\u66f4\u662f\u663e\u793a\u4ed6\u4f53\u5185\u7684HIV\u75c5\u6bd2<\/p>\n
\u51e0\u4e4e\u6240\u5269\u65e0\u51e0<\/p>\n
\u5982\u4eca\uff0c53\u5c81\u7684Timothy<\/p>\n
\u6bcf\u65e5\u5728\u7f8e\u56fd\u897f\u6d77\u5cb8\u9633\u5149\u7684\u6c90\u6d74\u4e0b<\/p>\n
\u575a\u6301\u953b\u70bc\u8eab\u4f53<\/p>\n
\u5728\u8eab\u4f53\u7684\u514d\u75ab\u7cfb\u7edf\u83b7\u5f97\u91cd\u5efa\u540e<\/p>\n
\u4ed6\u6536\u83b7\u4e86\u751f\u547d\u7684\u4e30\u76db\u4e0e\u7075\u9b42\u7684\u66f4\u65b0<\/p>\n
\u5f53Timothy\u57282007\u5e74\u88ab\u5e72\u7ec6\u80de\u79fb\u690d\u65b9\u6cd5<\/p>\n
\u6210\u529f\u6cbb\u7597\u827e\u6ecb\u75c5\u540e<\/p>\n
\u533b\u5b66\u754c\u56f4\u7ed5\u7740\u5728\u4ed6\u8eab\u4e0a\u8bde\u751f\u7684\u5947\u8ff9<\/p>\n
\u4ea7\u751f\u4e86\u8bb8\u591a\u7591\u95ee\uff1a<\/p>\n
Timothy\u73b0\u8c61<\/p>\n
\u662f\u4e00\u79cd\u5076\u7136\u8fd8\u662f\u5fc5\u7136\uff1f<\/p>\n
Timothy\u662f\u5426<\/p>\n
\u662f\u72ec\u4e00\u4f4d\u88ab\u4e0a\u5e1d\u683c\u5916\u5782\u9752\u7684\u5e78\u8fd0\u8005?<\/p>\n
Timothy\u7684\u6210\u529f<\/p>\n
\u662f\u5426\u53ef\u4ee5\u5728\u5176\u4ed6\u60a3\u8005\u8eab\u4e0a\u590d\u5236?<\/p>\n
\u8fd9\u4e00\u56f0\u6270\u572812\u5e74\u540e\u7684\u4eca\u5929\u7ec8\u4e8e\u5316\u89e3<\/p>\n
\u201c\u4f26\u6566\u75c5\u4eba\u201d\u7684\u6210\u529f\u6848\u4f8b<\/p>\n
\u8ba9\u4e00\u5411\u4e25\u8c28\u7684\u533b\u5b66\u754c\u66f4\u53ef\u4ee5\u76f8\u4fe1\uff1a<\/p>\n
Timothy\u7684\u6848\u4f8b\u771f\u7684\u4e0d\u662f\u5947\u8ff9<\/p>\n
\u6bcf\u4e00\u4f4d\u827e\u6ecb\u75c5\u60a3\u8005<\/p>\n
\u6216\u8bb8\u90fd\u53ef\u4ee5\u6210\u4e3a\u4e0b\u4e00\u4f4dTimothy<\/p>\n
\u8fd9\u4f4d\u201c\u4f26\u6566\u75c5\u4eba\u201d\u540c\u6837\u4e5f\u8eab\u60a3\u827e\u6ecb\u75c5+\u764c\u75c7<\/p>\n
\u4ed6\u6240\u60a3\u7684\u764c\u75c7\u4e3a\u970d\u5947\u91d1\u6dcb\u5df4\u7624<\/p>\n
\uff08 Hodgkin\u2019s lymphoma \uff09<\/p>\n
2016\u5e74\u65f6<\/p>\n
\u8fd9\u4f4d\u201c\u4f26\u6566\u75c5\u4eba\u201d\u63a5\u53d7\u4e86\u9020\u8840\u5e72\u7ec6\u80de\u9aa8\u9ad3\u79fb\u690d<\/p>\n
\u6350\u732e\u8005\u5e26\u6709CCR5\u7a81\u53d8\u4f9b\u4f53<\/p>\n
\uff08 CCR5 gene mutation\uff09<\/p>\n
\u8fd9\u540d\u60a3\u8005\u540c\u65f6\u670d\u7528\u4e86\u514d\u75ab\u6291\u5236\u836f\u7269<\/p>\n
\uff08 immunosuppresive drugs\uff09<\/p>\n
\u57282017\u5e749\u6708<\/p>\n
\u4ed6\u5f00\u59cb\u505c\u6b62\u670d\u7528\u6cbb\u7597\u827e\u6ecb\u75c5\u7684ART\u836f\u7269<\/p>\n
\u6765\u81ea\u58a8\u5c14\u672c\u5927\u5b66\u7684\u533b\u5b66\u5bb6<\/p>\n
\u540c\u65f6\u4e5f\u662f\u56fd\u9645\u827e\u6ecb\u75c5\u534f\u4f1a<\/p>\n
\u827e\u6ecb\u75c5\u6cbb\u7597\u9879\u76ee\u8054\u5408\u4e3b\u5e2d\u7684Sharon Lewin\u8868\u793a:<\/p>\n
\u201c\u8fd9\u540d\u60a3\u8005\u5df2\u7ecf\u505c\u6b62\u4f7f\u7528ART\u836f\u7269\u957f\u8fbe19\u4e2a\u6708<\/p>\n
\u4f53\u5185\u7684\u827e\u6ecb\u75c5\u6bd2\u5e76\u672a\u51fa\u73b0\u53cd\u5f39\u8ff9\u8c61<\/p>\n
\u533b\u5b66\u754c\u5c06\u5bc6\u5207\u5173\u6ce8\u4ed6\u4f53\u5185HIV\u75c5\u6bd2\u6570\u91cf\u7684\u53d8\u5316<\/p>\n
\u4f46\u540c\u65f6\u6211\u4eec\u4e5f\u6709\u7406\u7531\u76f8\u4fe1<\/p>\n
\u6765\u81eaCCR5\u9634\u6027\u4f9b\u4f53\u7684\u9aa8\u9ad3\u79fb\u690d<\/p>\n
\u6216\u8bb8\u53ef\u4ee5\u6d88\u9664HIV\u6b8b\u4f59\u75c5\u6bd2<\/p>\n
\u5e76\u963b\u6b62\u75c5\u6bd2\u5728\u4eba\u4f53\u91cd\u65b0\u590d\u53d1<\/p>\n
\u800c\u5e72\u7ec6\u80de\u7684CCR5\u57fa\u56e0\u6cbb\u7597<\/p>\n
\u53ef\u4ee5\u4f5c\u4e3a\u533b\u5b66\u754c\u63a2\u7d22\u827e\u6ecb\u75c5\u6cbb\u7597\u7684\u65b0\u7b56\u7565<\/p>\n
\u6089\u5c3c\u65b0\u5357\u5a01\u5c14\u58eb\u5927\u5b66\u7684Anthony Kelleher\u6559\u6388\u8868\u793a:<\/p>\n
\u4ee5\u4e0a\u4e24\u8d77\u75c5\u4f8b\u7684\u6210\u529f\u4e4b\u5904<\/p>\n
\u90fd\u7531\u4e8e\u60a3\u8005\u514d\u75ab\u7cfb\u7edf<\/p>\n
\u5f97\u5230\u4e00\u79cd\u66f4\u6539\u540e\u7684\u57fa\u56e0\uff08modified gene\uff09\uff1a<\/p>\n
CCR5 <\/p>\n
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\u57fa\u56e0\u7f16\u8f91\uff08Gene Editing\uff09\u6280\u672f<\/p>\n
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\u81ea\u827e\u6ecb\u75c5\u5f00\u59cb\u6d41\u884c\u4ee5\u6765<\/p>\n
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\u622a\u81f32017\u5e74\u5e95<\/p>\n
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\u8054\u5408\u56fd\u66fe\u4f5c\u51fa\u627f\u8bfa<\/p>\n
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\u6211\u4eec\u4e5f\u786e\u5b9e\u6b23\u559c\u7684\u770b\u5230<\/p>\n
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\u4ece\u4e0a\u4e16\u7eaa90\u5e74\u4ee3\u7684\u6bcf\u5e74300\u591a\u4e07<\/p>\n
\u4e0b\u964d\u52302017\u5e74\u7684180\u4e07<\/p>\n
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\u4ed6\u4eec\u773c\u7741\u7741\u7684\u770b\u7740\u81ea\u5df1\u7684\u8eab\u4f53<\/p>\n
\u4e00\u5929\u53c8\u4e00\u5929\u7684\u88ab\u6b7b\u795e\u62d6\u5411\u6bc1\u706d\u7684\u8fb9\u7f18<\/p>\n
\u5374\u65e0\u529b\u547b\u541f<\/p>\n
\u4ed6\u4eec\u5728\u9ed1\u6697\u7684\u65e0\u4eba\u89c2\u671b\u7684\u89d2\u843d\u9ed8\u9ed8\u6d41\u6cea<\/p>\n
\u4e00\u5e55\u53c8\u4e00\u5e55\u88ab\u4e16\u4eba\u51b7\u773c\u5632\u7b11\u907f\u4e4b\u4e0d\u53ca\u7684\u753b\u9762<\/p>\n
\u5982\u68a6\u9b47\u822c\u6d6e\u73b0\u5728\u773c\u524d<\/p>\n
2\u4f8b\u60a3\u8005<\/p>\n
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